The integration of structural and geochronological data indicates long-lasting polyphase deformation and metamorphism in the eastern Superior Province. Two discrete tectonometamorphic events, known as pre-D1 (2815-2804 Ma) and D1 (2756-2736 Ma), may record mid-crustal decoupling between a rigid upper crust and hotter, middle-to-lower crustal plutonic rocks (TTGs) prior to the Kenorean orogeny (2720-2680 Ma). Maximum depositional ages (<2724 Ma) for the Nemiscau indicates sedimentation during at least the early stages of the Kenorean orogeny. This was followed by D2 (2704-2677 Ma) dip-slip deformation coeval with granulite facies metamorphism and anatexis in the Nemiscau subprovince (2697-2685 Ma). A D3 dextral strike-slip deformation event at 2658-2621 Ma was accompanied by amphibolite facies metamorphism. A D4 deformation event, associated with localized brittle-to-ductile conjugated shear zones and decreasing crustal cooling from amphibolite to greenschist facies conditions, occurred at ≤2598 Ma. 40Ar/39Ar step-heating ages of hornblende grains suggest slow cooling following D3, between ~2625 and 2590 Ma. The 2590-2555 Ma ages of a second population of hornblende grains may imply crustal cooling following the emplacement of late-stage granitic intrusions, whereas 40Ar/39Ar muscovite ages suggest retrogression into greenschist facies at ~2535 Ma. Nd isotopic data (eNd -3.55, +1.61) and U-Pb ages of inherited zircons (2.91-3.46 Ga) argue for recycling of Paleo- to Mesoarchean continental crust during genesis of TTG suites (³2800 Ma) in the La Grande (TDM 3.52-3.08 Ga) and Opatica (TDM <3.07 Ga) subprovinces. The isotopic composition (eNd -1.12, +0.24) of younger TTGs (<2755 Ma) and syn- to late-tectonic intrusions (<2646 Ma) in the Nemiscau and Opatica subprovinces is consistent with the crustal evolutionary trend of the older Opatica TTG suites, suggesting that they originated by partial melting of these latter «basement» rocks. The emplacement of sanukitoid suites at 2704-2693 Ma in the La Grande and Opatica subprovinces is contemporaneous with the partial melting episode in the Nemiscau. εNd values (-0.61, +1.64) of these sanukitoids suggest a renewed mantle source (TDM 3.02-2.85 Ga) slightly perturbed by the incorporation of older crustal material. Mafic-to-ultramafic rocks of the greenstone belts have juvenile signatures that are consistent with depleted mantle sources. The associated intermediate and felsic volcanic rocks exhibit a wide range of εNd values (-1.87, +2.01), likely reflecting mixing of ~3.0 Ga mantle and >3.0 Ga crustal components. Our field and isotopic data show more similarities than differences between the La Grande, Nemiscau and Opatica subprovinces. This result suggests that they most likely represent a single composite terrane instead of distinct crustal blocks or microcontinents. The overall structural characteristics of the region are consistent with the evolution of a «hot» orogen, in which contemporaneous gravity processes and lateral extrusion of high-temperature crustal material affected the middle and lower crust.