Archean gold deposits in amphibolite facies rocks commonly have complex parageneses, in part due to superimposed deformation and metamorphism. In these conditions, gold may also be remobilized with other low melting point chalcophile metals (e.g. Bi, Ag, As, Sb), thus leading to equivocal deposit models. The Eeyou Istchee James-Bay area (Québec), in the southeastern Superior Province of Canada, hosts several gold deposits in amphibolite facies supracrustal rocks and intrusions. Many of these deposits, such as the Cheechoo deposit, are located in the La Grande subprovince, close to the contact with amphibolite to granulite facies metasedimentary rocks and migmatites of the Opinaca subprovince. The Cheechoo deposit (resources: 1.5 Moz @ 0.94 g/t Au indicated & 0.5 Moz @ 0.73 g/t Au inferred; Sirios Resources 43-101) is partially hosted by disseminated sulfide zones in granodiorite, but most of the resources are associated with auriferous granitic pegmatites, an uncommon feature to most Archean gold deposits. A detailed mineralogical, structural and U-Pb geochronological (LA-ICP-MS) study was initiated to constrain the genesis of this unusual deposit. The gold zones and the pegmatites are hosted by hornblende-biotite-bearing granodiorite, biotite-plagioclase-quartz±garnet metawacke, and biotite-sillimanite-plagioclase paragneiss. Preliminary metamorphic modelling on metasedimentary rocks indicates minimum temperature conditions in the upper amphibolite facies (~600oC). The granodiorite was hydrothermally altered prior to the main phase of compressive D2 deformation and late-kinematic peak metamorphism. Its chemical composition is similar to that of 2671-2636 Ma anatectic leucogranites in the adjacent Opinaca subprovince. It includes three main metamorphosed alteration types that do not show systematic association with gold-rich zones: albitization, calc-silicate (actinolite-plagioclase-diopside±garnet) and biotitization, with trace amounts of disseminated sulfides (arsenopyrite-pyrrhotite-lollingite). The disseminated mineralization is associated with quartz-plagioclase-diopside±scheelite veinlets, which are cut by later quartz±gold-scheelite veinlets. The mineralized pegmatites contain biotite, tourmaline, apatite and muscovite. They intruded the metasedimentary rocks and granodiorite after peak metamorphism, as suggested by mineralized tourmaline selvages replacing aluminosilicate porphyroblasts, and their emplacement along the axial planes of P3 folds and D3 dextral shear zones. They are in textural continuity with mineralized quartz-feldspar and quartz-tourmaline veinlets. They also contain maldonite (Au2Bi), native bismuth and gold, electrum, lollingite, arsenopyrite and pyrrhotite, which occur as melt inclusions in plagioclase and quartz, as interstitial grains, and in microscopic k-feldspar veinlets that cut across plagioclase crystals. The granodiorite yielded a zircon crystallization of ~2640 Ma, whereas metamorphic monazite from the metasedimentary rocks was dated at ~2609 Ma. Two pegmatite dykes yielded ages of ~2570 and 2566 Ma on U-rich zircon rims, which are considered minimum estimates because of possible lead loss due to radiation damage. These data indicate that the granodiorite was hydrothermally altered and mineralized between 2640 and 2609 Ma. Prograde metamorphism peaked at upper amphibolite facies, possibly resulting in Au-Ag-As-Bi remobilization, consistent with the localized and variable Au concentration in the disseminated mineralization. The subsequent emplacement of auriferous pegmatites and associated veinlets between 2609 and 2570 Ma contributed to Au scavenging and to its concentration in melts and hydrothermal fluids within late structural sites in a dextral shear regime.