Although the 2.2–2.1 Ga magmatism was extremely active globally, the crust evolutionary scenarios and geodynamic driving mechanisms during this stage are still lacking comprehensive understanding. The present study verifies that the the 2.2–2.1 Ga A-type granites are formed in the eastern North China Craton (NCC), and could provide further constraints for revealing the paleoproterozoic tectonic evolutional processes. This study presents geochemistry, U-Pb dating and zircon Hf-O isotopes of the ca. 2.1 Ga A-type granites distributed in the Dongbaishi and Gujiacun areas in the Jiaobei Terrane, eastern North China Craton. The two plutons were metamorphosed at 1.9–1.8 Ga, and preseved inherited ages of ca. 2.7 Ga. The Dongbaishi pluton consists of quartz syenite, monzogranite and syenogranite, and Gujiacun pluton is composed of granodiorite and monzogranite, both of which show metaluminous and calc-alkaline characteristics. They display decreasing Fe2O3T, TiO2, Al2O3, CaO, Na2O and P2O5, but increasing K2O, with increasing SiO2 contents, indicating that Fe-Ti oxide, plagioclase and apatite were fractionated during magmatic evolution, which is confirmed by the negative Eu, Sr, P, and Ti anomalies. The high Ga/Al ratios, Zr+Nb+Y+Ce contents and Zr saturation temperatures (850℃ on average) of these granites are consistent with the features of A-type granite. Dongbaishi quartz syenite yields zircon εHf(t) values of 0.98 to 6.52 with two-stage Hf model ages (TDM2(Hf)) of 2.29–2.65 Ga, along with no obvious K2O vs. MgO correlations, indicating the contribution of mantle-derived materials with potassium-rich minerals in the source. Dongbaishi monzogranite and syenogranite and Gujiacun monzogranite have zircon εHf(t) values of -3.76 to 4.14 with two-stage Hf model ages (TDM2(Hf)) of 2.93–2.51Ga. The two plutons have high K2O/Na2O, low MgO contents (Mg# = 24–33), low CaO/(FeOt + MgO) ratio, low to moderate Al2O3/TiO2, Rb/Sr and Rb/Ba ratios, commonly implying metasediments-dominated sources. In-situ zircon δ18O values (5.48-12.2‰, 9.15‰ on average) of Dongbaishi and Gujiacun plutons (6.05-7.32‰, 6.77‰ on average) are higher than that of mantle, further confirming the contribution of sedimental materials in the source. Combing the high zircon δ18O signature, A-type geochemical features, and those published for 2.2–2.1 Ga granites and gabbros in eastern NCC, we suggest a thermal anomaly linked to a rift setting could account for the middle to shallower crustal melting. The rifting activity in the NCC during 2.2–2.1 Ga may coincided with the global lithospheric break-up of the supercontinent, and the subsequent tectonic transition could correspond to development of the globally orogenesis at 2.1–1.8 Ga.