The Hoggar region, belonging to the Tuareg Shield, represents one of the most economic regions in Algeria. In Central Hoggar, the Proterozoic terranes of Serouenout and Azrou N'Fad are characterized by the pronounced hydrothermal alteration of their basement/cover rocks. These latter constitute potential hosts for rare earth elements (REE) and other economic minerals. In our study, we give a special interest to radioactive elements and their associated alteration minerals. From this perspective and from previous field observations, we propose to map a portion of the Serouenout terrane lying between two major faults that had supposedly played an important role accommodating for mineral deposits. Our methodology consists on using combined remote sensing data from ASTER images and airborne radiometric surveys in order to detect anomalies of radioactive minerals corresponding to K, Th and U surface concentrations and to map the related potential economic ore bodies. The preliminary results from the conversion of airborne radiometric data, showing anomalies of radioactive element concentrations i.e. U, Th, K %, are consistent with some of the remotely sensed and field observed hydrothermal alteration minerals, mostly associated to granites, which are known to be concentrating such elements. U/Th and U/K ratios permitted delineating tracts for potential ore bodies with the highest anomalies of uranium concentrations and which might be of a significant economic interest. Pairing airborne radiometric data with hydrothermal alteration maps from ASTER images provide valuable information for radioactive mineral detection. This combination method is particularly time efficient as it helps avoid other -more likely sterile- hydrothermal alteration locations during field investigations.