Giant spodumene pegmatite deposits at Pilgangoora and Wodgina are part of an extensive lithium-rich pegmatite district on the western margin of the East Pilbara Terrane, within the northern Pilbara Craton. Here, regional deformation is manifested by faults, folds, and shear zones within ~3.18 Ga greenstone belts, and mylonite and gneissic foliation in the surrounding ~2.95-2.85 Ga granitic complexes. A four-fold deformation scheme is developed from regional mapping, and study of pegmatites and wall rocks at individual deposits. D4 controlled the location of ~2.85 Ga spodumene pegmatite intrusions. D4 was progressive and comprises: a) macroscopic F4a subvertical folds and D4a fault arrays, and; b) D4b ductile shear zones with upright S and L-S fabrics that transpose D4a structures. Regionally, S4b is inclined steeply towards the WNW, and L4b plunge obliquely towards either the north or south. However, D4b shear zones at Pilgangoora and Wodgina are distinct (Figure 1), wherein there are two S4b fabrics present, namely main fabric domains inclined steeply towards the WNW and subsidiary fabric domains locally aligned with oblique D4a faults. L4b in both fabric domains are co-linear and plunge steeply. Such strain compatibility indicates synchronous ductile flow to form the main and subsidiary S4b fabric domains. Spodumene pegmatite intrusions at Pilgangoora and Wodgina are mostly en echelon sheets inclined gently towards the ESE, opposite to the inclination of the main fabric domains. The sheets are up to 1000 m-long and 100 m-thick, and terminate laterally by tapering, or by pinching out against subsidiary fabric domains. Sheet formation reflects tensile shear failure and magmatic inflation in a coaxial brittle-ductile regime. Closely spaced D4a faults acted as passive attractors of coaxial strain, and the subsidiary and main S4b fabric domains record strong subvertical extrusion of fault blocks during constriction. Localised constriction at Pilgangoora and Wodgina contrasts starkly with the regional D4b strain pattern, which reflects oblique extrusion during transpression. Spodumene pegmatite intrusions exhibit remarkable structural controls, and structural mapping and analysis is a critical step for locating new deposits in Archaean terranes.